2019/10/9上午

11:00~12:00

Biomimetic ceramic composites for chairside CAD/CAM dental restorations

Machinable ceramics which could be used as a chairside CAD/CAM material that only needs minutes for dental treatment are highly desirable. In this talk, we will discuss the potential of a nacre-like alumina/UDMA composite with brick & mortar structure for such an application.

2019/10/9下午

15:00~16:00

Investigating bactericidal mechanisms for contact killing nanotopographies using electron tomography and quantitative proteomic analysis

Given the significant failure rates in treating medical device-associated infections with antibiotics, novel approaches are urgently needed to prevent the development of pathogenic biofilms on titanium devices. Inspired by nature, we aim to generate titanium nanostructure arrays that efficiently kill bacteria upon contact, via physical rupture of the bacterial envelope. We hope to apply this technology to the rational design of next generation, anti-infective implants. A simple thermal oxidation was used to create bio-inspired titanium dioxide nanostructure arrays on titanium alloy surfaces. The antibacterial performance of nanostructured surfaces was determined by advanced fluorescence microscopy and metabolic indicator assays.

2019/10/10上午

11:00~12:00

Rational design and fabrication of antimicrobial polymer surfaces based on biomimetic nanotopography

We aim to understand how the differences in topography affect the bactericidal properties experimentally and theoretically. Two nanopatterning methods (colloidal lithography and anodisation/hot embossing) were used to design different polymeric nanopillars on polyethylene terephthalate (PET) substrate that differs in terms of sharpness and density of the nanopillars. Ti was found that the sharper and denser nanopillars had the best bactericidal performance when compared to the other nanostructured surfaces.

2019/10/10下午

15:00~16:00

Synergistic antimicrobial implant surfaces functionlised with enzyme and peptides

The approach taken in this study is to functionalise TiO₂ nanowires with the bactericidal enzyme, lysostaphin. Such a multi-faceted, synergistic approach, whereby Gram-negative cells are mechanically killed and Gram-positive cells are chemically killed, has led to the generation of a multi-functional bactericidal surface which has the potential to be used in medical implants.